Animal Care and Use Program Experience
CURRICULUM VITAE
- Program Development and Management
- Facilities and Program Development
- Species experience
- Fiscal Management
- IACUC Experience
- Training Presented in Animal Research
Education
B.S. 1964 Canisius College, Buffalo, NY (Biology)
Ph.D. 1969 Department of Biological Sciences, Purdue University, Lafayette, IN
Developmental Biology, Cell Biology, Bionucleonics
Thesis Title: "An Analysis of Gland Rudiment Initiation in Xenopus Laevis Epidermis"
Post-Doctorate 1968-1970 Division of Experimental Biology, Baylor College of Medicine, Houston, TX John. J. Trentin, Ph.D., Hematopoiesis, Immunology, Virology
Research and Program Development
1975 - began the development for RPCI of a 19 acre remote facility to provide research resources and services for Institute Basic and Clinical investigators - polyclonal antibodies in rabbits, goats, sheep, chickens and turkeys; hybridoma passage for ascites; blood and tissue resources (e.g. defibrinated sheep red cells, tissues and organs from a variety of species); contract research/surgical support using several species;production colonies of beagle dogs and genetically defined mice (10 inbred, congenic and transgenic lines). The site was 40 miles from the main RPCI campus, had 6 buildings (>10,000 nsf animal care space) and 14 technical, husbandry, clerical and maintenance staff.
1985 - Founding Director of the Department of Laboratory Animal Resources (DLAR) consolidating the >18 independent animal care sites and 68 total staff under a single administrative Institute authority.
Facilities:
2000 - joined the Laboratory of Dr. James Lee to continue collaborative studies (initiated in 1992) on the effector cell functions of eosinophil granulocytes and serve as Director of the Mayo Clinic Arizona Laboratory Animal Resource Core/Gene Transfer Laboratory, a 10,000 nsf barrier facility for the production and maintenance of genetically engineered and mutant mice as well as SPF rats, hamsters, rabbits and dogs for Mayo Clinic Arizona basic and clinical investigators.
2003 - appointed Director of the Animal Care Program at Arizona State University, organizing it as the Department of Animal Care and Technologies (DACT). During the ensuing 4 years in addition to several renovation projects, three animal care and use facilities were designed, constructed, commissioned and occupied, and staff recruited and trained:
Species experience
Mice (conventional, VAF, SPF, germfree, ABSL/2 and ABSL/3), rats (conventional, SPF and germfree), rabbits, guinea pigs, dogs, cats, farm species (calves, sheep, goats, Yorkshire and micro- and mini-pigs, chickens, quail, turkeys), fish, amphibians, reptiles, birds (pigeons, finches, hummingbirds, ducks, etc.), nonhuman primates (yellow and olive baboons, stumptail and rhesus macaques). Holdings have included breeding colonies of 12 inbred, 6 hybrid and 1 random bred strain of mice, of transgenic, knockout, nude and SCID mice as well as others with specific mutations of interest, athymic nude and polycystic kidney disease rats and beagle dogs.
Fiscal Management
The RPCI combined State, Institutional, chargeback and NIH grant support requiring several Cost Centers. Dr. McGarry developed and implemented a system for per diem charges for husbandry and services based on the NIH Rate-Setting Guide. Satellite facility budgets included all aspects of building and maintenance needs. Contract research budgets were developed and managed for all extramural research collaborations. Growth at RPCI and ASU from a few hundred thousand to several million dollars annual budget.
IACUC Experience
1985 - Dr. McGarry initiated and administered the RPCI Institute Animal Care and Use Committee, was founding Chairman, serving 8 years, then continued as a committee member, accomplishing initial documentation and compliance with USDA and NIH/OPRR (OLAW)-mandated rules for review of >350 research protocols. While at the Mayo Clinic Arizona, he was appointed to the Mayo Foundation IACUC, serving from 2000-2003. During this time research protocols he wrote for the Lee Laboratories became models for Foundation-wide use. He served for 4 years on the ASU IACUC, authoring several protocols for extramural contract research done within DACT facilities.
Technical and Professional Training Provided in Animal Research Techniques
At Roswell Park Cancer Institute:
Biology of the Laboratory MouseThe Ethical Conduct of Research
Use of Animals in Biomedical Research
Techniques in Experimental Pathology - Methods of Lab Animal Care and Use
Animal Models for In Vivo Studies in Immunology
Biosafety cabinet use in containment and barrier microisolator husbandry
Workshops for technical and professional staff on standards for animal care and use, selected procedures (injections, blood collection, necropsy, tumor transplant), biology and breeding of the lab mouse;
Monthly Animal Care Staff In-Services
At Mayo Clinic – Arizona:
Workshops for technical and professional staff on standards for animal care and use, selected procedures, biology and breeding of the lab mouse;AALAS Lab Animal Technician Certification Training Courses
At Arizona State University:
AALAS Lab Animal Technician Certification Training CoursesMonthly Department In-Services
Biosafety cabinet use in containment and barrier microisolator husbandry, including use of select agents
In addition:
Standard Operating Procedures Manuals for Species-Specific and Husbandry, Equipment Processing and Health at each Institution;Laboratory Procedures Manual for Antibody Production in Rabbits –
Workshop for 1991 National AALAS meeting;
Supplementary Manuals for intramural workshops on anesthesia, injection and sampling procedures, breeding colony management, husbandry procedures and biology of laboratory animals.
National AALAS District 1 Training Seminar lecture "Breeding and Husbandry of Transgenic Mice", Albany, NY, 1995.